ANTINE 20mg Tablets - (Ebastine 20mg)


Ebastine is a long-acting and selective H1-histamine receptor antagonist. After repeated administration, inhibition of peripheral receptors remain at a constant level. Ebastine is rapidly absorbed and undergoes extensive first pass metabolism following oral administration. Ebastine is almost totally converted to the pharmacologically active acid metabolite, carebastine. After a single 10 mg oral dose, peak plasma levels of carebastine occur at 2,6 to 4 hours and achieve levels of 80 to 100 ng/mL. The half-life of carebastine is between 15 and 19 hours with 66% of the medicine being excreted in the urine mainly as conjugated metabolites. 

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